Journal
FEBS JOURNAL
Volume 276, Issue 8, Pages 2348-2358Publisher
WILEY
DOI: 10.1111/j.1742-4658.2009.06967.x
Keywords
adipocyte; differentiation; hypoxia; microRNA; obesity
Categories
Funding
- Oak Ridge Institute for Science and Education
- Air Force Research Laboratory, Brooks City-Base, TX, USA.
Ask authors/readers for more resources
MicroRNAs (miRNAs) are involved in a plethora of important biological processes, from embryonic development to homeostasis in adult tissues. Recently, miRNAs have emerged as a class of epigenetic regulators of metabolism and energy homeostasis. We have investigated the role of miRNAs in the regulation of adipogenic differentiation. In this article, we demonstrate that the miR-27 gene family is downregulated during adipogenic differentiation. Overexpression of miR-27 specifically inhibited adipocyte formation, without affecting myogenic differentiation. We also found that expression of miR-27 resulted in blockade of expression of PPAR gamma and C/EBP alpha, the two master regulators of adipogenesis. Importantly, expression of miR-27 was increased in fat tissue of obese mice and was regulated by hypoxia, an important extracellular stress associated with obesity. Our data strongly suggest that miR-27 represents a new class of adipogenic inhibitors and may play a role in the pathological development of obesity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available