Human telomeric G-quadruplex: targeting with small molecules (Retraction of vol 6, pg 627, 2008)

Over the past few decades, numerous small molecules have been designed to specifically and selectively target the unusual secondary structure in DNA called the G-quadruplex. Because these ligands have been shown to selectively inhibit the growth of cancer cells, they have become a central focus for the development of novel anticancer agents. However, there are many challenges which demand greater effort in order to devise strategies for rational drug design with utmost selectivity. This minireview aims to reflect recent developments in the design of G-quadruplex ligands and also discusses the future outlook for designing more effective G-quadruplex interacting ligands.