Related references
Note: Only part of the references are listed.Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls
Javier Simon-Sanchez et al.
HUMAN MOLECULAR GENETICS (2008)
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease
Veerle Bogaerts et al.
HUMAN MUTATION (2008)
Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome:: implications for Parkinson's disease aetiology
Begona Caneda-Ferron et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease
Fang Liu et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Characterization of PINK1 processing, stability, and subcellular localization
William Lin et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Parkin mediates the degradation-independent ubiquitination of Hsp70
Darren J. Moore et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Loss of PINK1 function affects development and results in neurodegeneration in zebrafish
Oleg Anichtchik et al.
JOURNAL OF NEUROSCIENCE (2008)
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
Anthony H. V. Schapira
LANCET NEUROLOGY (2008)
The promise of human induced pluripotent stem cells for research and therapy
Shin-ichi Nishikawa et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner
Yasuhiro Moriwaki et al.
NEUROSCIENCE RESEARCH (2008)
PINK1 in mitochondrial function
Helene Plun-Favreau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
M. Emdadul Haque et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
Clement A. Gautier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The PINK1/Parkin pathway regulates mitochondrial morphology
Angela C. Poole et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
John T. Dimos et al.
SCIENCE (2008)
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1
Andreas Weihofen et al.
HUMAN MOLECULAR GENETICS (2008)
Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
Wonsuk Yang et al.
HUMAN MOLECULAR GENETICS (2007)
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
Nicole Exner et al.
JOURNAL OF NEUROSCIENCE (2007)
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Helene Plun-Favreau et al.
NATURE CELL BIOLOGY (2007)
Downregulation of parkin damages antioxidant Defenses and enhances proteasome inhibition-induced toxicity in PC12 cells
Hai Yang et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2007)
Pathogenic mutations in Parkinson disease
Eng-King Tan et al.
HUMAN MUTATION (2007)
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease
Mark W. Dodson et al.
CURRENT OPINION IN NEUROBIOLOGY (2007)
Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
Eyal Avraham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212
Lin Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
DJ-1: A new comer in Parkinson's disease pathology
Cristine Alves da Costa
CURRENT MOLECULAR MEDICINE (2007)
Understanding the molecular causes of Parkinson's disease
A. Wood-Kaczmar et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Parkinsonism genes: culprits and clues
Asa Abeliovich et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila
Danling Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3) K-Akt signalling
Lara Fallon et al.
NATURE CELL BIOLOGY (2006)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
Miratul M. K. Muqit et al.
JOURNAL OF NEUROCHEMISTRY (2006)
PINK1 protein in normal human brain and Parkinson's disease
S. Gandhi et al.
BRAIN (2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark et al.
NATURE (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
Beisha Tang et al.
HUMAN MOLECULAR GENETICS (2006)
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline
MJ Casarejos et al.
JOURNAL OF NEUROCHEMISTRY (2006)
The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein
WB Zhou et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Expanding insights of mitochondrial dysfunction in Parkinson's disease
PM Abou-Sleiman et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y
H Deng et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
The mitochondrial death squad: hardened killers or innocent bystanders?
PG Ekert et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
L Silvestri et al.
HUMAN MOLECULAR GENETICS (2005)
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
YF Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
M Meulener et al.
CURRENT BIOLOGY (2005)
Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers
PP Pramstaller et al.
ANNALS OF NEUROLOGY (2005)
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
KM Strauss et al.
HUMAN MOLECULAR GENETICS (2005)
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
L Zhang et al.
HUMAN MOLECULAR GENETICS (2005)
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
E Junn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
J Xu et al.
HUMAN MOLECULAR GENETICS (2005)
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
A Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
DJ-1, a novel regulator of the tumor suppressor PTEN
RH Kim et al.
CANCER CELL (2005)
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
A Yamamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
DJ Moore et al.
HUMAN MOLECULAR GENETICS (2005)
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
JA Olzmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease
K Hedrich et al.
NEUROLOGY (2004)
DJ-1 has a role in antioxidative stress to prevent cell death
T Taira et al.
EMBO REPORTS (2004)
How does parkin ligate ubiquitin to Parkinson's disease? First in molecular medicine review series
PJ Kahle et al.
EMBO REPORTS (2004)
Oxidative stress in neurodegeneration: cause or consequence?
JK Andersen
NATURE MEDICINE (2004)
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
RM Canet-Avilés et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
DJ-1 is a redox-dependent molecular chaperone that inhibits α-synuclein aggregate formation
S Shendelman et al.
PLOS BIOLOGY (2004)
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: An ES-derived cell model of primary Parkinsonism
C Martinat et al.
PLOS BIOLOGY (2004)
PINK, PANK, or PARK?: A clinicians' guide to familial parkinsonism
DG Healy et al.
LANCET NEUROLOGY (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
Y Pesah et al.
DEVELOPMENT (2004)
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
T Yokota et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Inactivation of parkin by oxidative stress and C-terminal truncations - A protective role of molecular chaperones
KF Winklhofer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain
SJ Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Molecular pathways of neurodegeneration in Parkinson's disease
TM Dawson et al.
SCIENCE (2003)
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
DW Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The role of pathogenic DJ-1 mutations in Parkinson's disease
PM Abou-Sleiman et al.
ANNALS OF NEUROLOGY (2003)
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation
S Hague et al.
ANNALS OF NEUROLOGY (2003)
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
F Darios et al.
HUMAN MOLECULAR GENETICS (2003)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
Immunocytochemical localization of DJ-1 in human male reproductive tissue
K Yoshida et al.
MOLECULAR REPRODUCTION AND DEVELOPMENT (2003)
Parkin protects against the toxicity associated with mutant α-synuclein:: Proteasome dysfunction selectively affects catecholaminergic neurons
L Petrucelli et al.
NEURON (2002)
Effect of wild-type or mutant parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome
DH Hyun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Lewy bodies and parkinsonism in families with parkin mutations
M Farrer et al.
ANNALS OF NEUROLOGY (2001)
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
M Unoki et al.
ONCOGENE (2001)
Parkin is associated with cellular vesicles
S Kubo et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Parkin is metabolized by the ubiquitin/proteosome system
P Choi et al.
NEUROREPORT (2000)
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on differentiating mouse N2a neuroblastoma cells
LA De Girolamo et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)