Journal
FEBS JOURNAL
Volume 275, Issue 17, Pages 4263-4270Publisher
WILEY
DOI: 10.1111/j.1742-4658.2008.06562.x
Keywords
autophagy; Huntington's disease; lithium; mTOR; polyglutamine; rapamycin
Categories
Funding
- Medical Research Council [G0600194] Funding Source: researchfish
- MRC [G0600194] Funding Source: UKRI
- Medical Research Council [G0600194, G0600194(77639)] Funding Source: Medline
- Wellcome Trust [064354] Funding Source: Medline
Ask authors/readers for more resources
Autophagy is a nonspecific bulk degradation pathway for long-lived cytoplasmic proteins, protein complexes, or damaged organelles. This process is also a major degradation pathway for many aggregate-prone, disease-causing proteins associated with neurodegenerative disorders, such as mutant huntingtin in Huntington's disease. In this review, we discuss factors regulating the degradation of mutant huntingtin by autophagy. We also report the growing list of new drugs/pathways that upregulate autophagy to enhance the clearance of this mutant protein, as autophagy upregulation may be a tractable strategy for the treatment of Huntington's disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available