Journal
FEBS JOURNAL
Volume 275, Issue 16, Pages 4005-4013Publisher
WILEY
DOI: 10.1111/j.1742-4658.2008.06558.x
Keywords
apoptosis; Bcl-2 family proteins; cardiolipin; ischemia; mitochondria; PKC epsilon; PMPT; phospholipid scramblase 3; ROS; TRAIL
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Mitochondria, which are the cellular energy plants, also act as the integration center of cellular signaling pathways. Apoptosis is a well-known pathway in which mitochondria are involved. Protein kinase C epsilon has been classified as a novel type of protein kinase C and is involved in many cellular events regulating mitochondrial function. Much evidence has accumulated regarding the relationships between mitochondria-mediated apoptosis and protein kinase C epsilon. Therefore, by focusing on these relationships, in particular the anti-apoptotic effects of protein kinase C epsilon on mitochondrial function, we highlight the importance and significance of protein kinase C epsilon in cell survival and death.
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