Journal
FEBS JOURNAL
Volume 275, Issue 16, Pages 3995-4004Publisher
WILEY
DOI: 10.1111/j.1742-4658.2008.06557.x
Keywords
actin; contraction; cytoskeleton; keratin; PKC epsilon
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Recent studies have established essential roles of protein kinase C epsilon in signaling pathways controlling various functions of microfilaments and intermediate filaments by modulating multiple cytoskeletal proteins. This review summarizes recent progress in our understanding of the roles of protein kinase C epsilon in the functions and signaling of microfilaments and intermediate filaments, with a focus mainly on cell-matrix and cell-cell interactions, migrations and contraction, in addition to its relevance in the development of several diseases, such as malignant tumors or cardiac disease.
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