Journal
FEBS JOURNAL
Volume 275, Issue 22, Pages 5512-5526Publisher
WILEY
DOI: 10.1111/j.1742-4658.2008.06696.x
Keywords
antioxidant; apoptosis; cancer prevention; cancer therapy; chemical structure; drugs; modulation; natural extracts; polyphenols; proteasome
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The purpose of this review is to discuss the effect of natural antioxidant compounds as modulators of the 20S proteasome, a multi-enzymatic multi-catalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell-cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.
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