Journal
FASEB JOURNAL
Volume 27, Issue 9, Pages 3414-3423Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.12-220418
Keywords
calcium; electrical activity; neurodegeneration
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale
- Fondation pour la Recherche Medicale
- program Investissements d'Avenir [ANR-10-IAIHU- 06]
- Association France Parkinson
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Parkinson disease (PD) is a degenerative brain disorder characterized by motor symptoms that are unequivocally associated with the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Although our knowledge of the mechanisms that contribute to DA cell death in both hereditary and sporadic forms of the disease has advanced significantly, the nature of the pathogenic process remains poorly understood. In this review, we present evidence that neurodegeneration occurs when the electrical activity and excitability of these neurons is reduced. In particular, we will focus on the specific need these neurons may have for stimulation in order to survive and on the molecular and cellular mechanisms that may be compromised when this need is no longer met in PD.Michel, P. P., Toulorge, D., Guerreiro, S., Hirsch, E. C. Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease.
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