Journal
FASEB JOURNAL
Volume 27, Issue 9, Pages 3424-3429Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.12-223842
Keywords
Parkinson's disease; LRRK2; GBA
Categories
Funding
- Michael J. Fox Foundation
- Parkinson's UK [F1002]
- Rosetrees Trust
- Wellcome Trust/Medical Research Council (MRC) [WT089698]
- Medical Research Council [MC_G1000735] Funding Source: researchfish
- Parkinson's UK [F-1002] Funding Source: researchfish
- MRC [MC_G1000735] Funding Source: UKRI
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The past decade has witnessed huge advances in our understanding of the genetics underlying Parkinson's disease. Identifying commonalities in the biological function of genes linked to Parkinson's provides an opportunity to elucidate pathways that lead to neuronal degeneration and eventually to disease. We propose that the genetic forms of Parkinson's disease largely associated with -synuclein-positive neuropathology (SNCA, LRRK2, and GBA) are brought together by involvement in the autophagy/lysosomal pathway and that this represents a unifying pathway to disease in these cases.Manzoni, C., Lewis, P. A. Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
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