Journal
FASEB JOURNAL
Volume 27, Issue 1, Pages 350-358Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.12-210724
Keywords
Fads2; flaxseed oil; polyunsaturated fatty acids; DNA methylation; postnatal development
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Funding
- University of North Carolina Center for Excellence in Children's Nutrition
- Mead Johnson Nutrition
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Previous studies indicated that the intake of alpha-linolenic acid (ALA) can alter the concentration of both omega-6 and omega-3 fatty acids in both mother and offspring, with consequences on postnatal brain development. This study describes the association between maternal ALA availability during gestation and lactation, and alterations in the Fads2 DNA methylation in both maternal and offspring livers, at the end of lactation period. Both Fads2 promoter and intron 1 DNA methylation were increased in the groups receiving postnatal flaxseed oil containing 50% ALA (mothers or pups), while bivariate analysis indicated a significant association of the Fads2 epigenetic status in the liver between each mother and its offspring. In addition, Fads2 expression was negatively correlated with promoter methylation at the individual level in maternal livers (P<0.05). This study also indicated that the interplay between ALA availability during gestation and lactation can differentially alter the expression of desaturases and elongases involved in omega-6 and omega-3 metabolic pathways. In summary, when considering the perinatal dietary ALA requirements in mice, both gestation and lactation periods should be considered as having distinct roles in modulating the metabolism of omega-6 and omega-3 fatty acids in maternal mouse livers.-Niculescu, M. D., Lupu, D. S., Craciunescu, C. N. Perinatal manipulation of alpha-linolenic acid intake induces epigenetic changes in maternal and offspring livers. FASEB J. 27, 350-358 (2013). www.fasebj.org
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