Related references
Note: Only part of the references are listed.Regulation and Functional Significance of Autophagy in Respiratory Cell Biology and Disease
Avignat S. Patel et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)
Targeting Energetic Metabolism A New Frontier in the Pathogenesis and Treatment of Pulmonary Hypertension
Rubin M. Tuder et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Pulmonary hypertension in lymphangioleiomyomatosis: characteristics in 20 patients
Vincent Cottin et al.
EUROPEAN RESPIRATORY JOURNAL (2012)
Targeting the Adventitial Microenvironment in Pulmonary Hypertension: A Potential Approach to Therapy that Considers Epigenetic Change
Kurt R. Stenmark et al.
Pulmonary Circulation (2012)
Pulmonary hypertension: the science behind the disease spectrum
M. R. Wilkins
EUROPEAN RESPIRATORY REVIEW (2012)
mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia
Vera P. Krymskaya et al.
FASEB JOURNAL (2011)
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
Iwona Fijalkowska et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3β and p70 ribosomal S6 kinase
Huan Deng et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2010)
Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA
Brad R. S. Broughton et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2010)
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor
Bao Hoang et al.
BLOOD (2010)
AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
Christine M. Chresta et al.
CANCER RESEARCH (2010)
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
Adem Kalender et al.
CELL METABOLISM (2010)
Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies
Stephen L. Archer et al.
CIRCULATION (2010)
The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma (Publication with Expression of Concern. See vol. 25, pg. 4194, 2019)
Daniel C. Cho et al.
CLINICAL CANCER RESEARCH (2010)
Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
Takeshi Kaizuka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
Didier Roulin et al.
MOLECULAR CANCER (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
Matthew R. Janes et al.
NATURE MEDICINE (2010)
Critical roles for mTORC2-and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
Nathalie Carayol et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension
Gopinath Sutendra et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
R. J. Shaw
ACTA PHYSIOLOGICA (2009)
mTOR's role in ageing: protein synthesis or autophagy?
Sarah L. Hands et al.
AGING-US (2009)
Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension
Aiko Ogawa et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)
Regulation by FK506 and rapamycin of Ca2+release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR
D. MacMillan et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension
C. Agard et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
PI3K/mTORC1 activation in hamartoma syndromes Therapeutic prospects
Vera P. Krymskaya et al.
CELL CYCLE (2009)
An Emerging Role of mTOR in Lipid Biosynthesis
Mathieu Laplante et al.
CURRENT BIOLOGY (2009)
mTOR signaling at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2009)
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
Mohamed Izikki et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
Nicholas W. Morrell et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Inflammation, Growth Factors, and Pulmonary Vascular Remodeling
Paul M. Hassoun et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Updated Clinical Classification of Pulmonary Hypertension
Gerald Simonneau et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
HIF-1 alpha Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms
Alvaro Marin-Hernandez et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
The multiple facets of mTOR in immunity
Thomas Weichhart et al.
TRENDS IN IMMUNOLOGY (2009)
Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation
Seiichiro Sakao et al.
RESPIRATORY RESEARCH (2009)
Mitochondrial metabolism, redox signaling, and fusion:: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer
Stephen L. Archer et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
Violeta Serra et al.
CANCER RESEARCH (2008)
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function
Amelia Barilli et al.
CARDIOVASCULAR RESEARCH (2008)
Cancer cell metabolism: Warburg and beyond
Peggy P. Hsu et al.
CELL (2008)
Inhibition of Apoptosis Through Localized Delivery of Rapamycin-Loaded Nanoparticles Prevented Neointimal Hyperplasia and Reendothelialized Injured Artery
Maram K. Reddy et al.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2008)
Pulmonary hypertension in interstitial lung disease
J. Behr et al.
EUROPEAN RESPIRATORY JOURNAL (2008)
Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2
Alfredo Toschi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A. Engelman et al.
NATURE MEDICINE (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Hypoxia-Induced Energy Stress Inhibits the mTOR Pathway by Activating an AMPK/REDD1 Signaling Axis in Head and Neck Squamous Cell Carcinoma
Abraham Schneider et al.
NEOPLASIA (2008)
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Bradly G. Wouters et al.
NATURE REVIEWS CANCER (2008)
Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study
M. Sean McMurtry et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
Renate Paddenberg et al.
RESPIRATORY RESEARCH (2007)
Alterations of cellular bioenergetics in pulmonary artery endothelial cells
Weiling Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2
Weimin Li et al.
CIRCULATION RESEARCH (2007)
Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase
Weilin Zhou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)
Pathology of pulmonary hypertension
Rubin M. Tuder et al.
CLINICS IN CHEST MEDICINE (2007)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
Hypoxia- and non-hypoxia-related pulmonary hypertension - Established and new therapies
Hossein A. Ghofrani et al.
CARDIOVASCULAR RESEARCH (2006)
Hypoxia-induced pulmonary vascular remodeling - Cellular and molecular mechanisms
Kurt R. Stenmark et al.
CIRCULATION RESEARCH (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
Cross talk between endothelial and smooth muscle cells in pulmonary hypertension - Critical role for serotonin-induced smooth muscle hyperplasia
S Eddahibi et al.
CIRCULATION (2006)
Hypoxia-induced energy stress regulates mRNA translation and cell growth
LP Liu et al.
MOLECULAR CELL (2006)
Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1
YL Liu et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)
Reversal of experimental pulmonary hypertension by PDGF inhibition
RT Schermuly et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Inhibition of rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
JM Hyvelin et al.
CIRCULATION RESEARCH (2005)
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension
SL Merklinger et al.
CIRCULATION (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation
EV Gerasimovskaya et al.
JOURNAL OF APPLIED PHYSIOLOGY (2005)
Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase
KA Fagan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension
Y Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells -: A novel mechanism of hypoxic pulmonary hypertension
MJ Lin et al.
CIRCULATION RESEARCH (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas et al.
GENES & DEVELOPMENT (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
Elevated basic fibroblast growth factor levels in patients with pulmonary arterial hypertension
JI Benisty et al.
CHEST (2004)
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells
S Zhang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
AM Arsham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee et al.
CURRENT BIOLOGY (2003)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
GENES & DEVELOPMENT (2003)
Pulmonary hypertension in chronic obstructive pulmonary disease
JA Barberà et al.
EUROPEAN RESPIRATORY JOURNAL (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells
EA Goncharova et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization.
M Morice et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR) -dependent signaling
R Humar et al.
FASEB JOURNAL (2002)
Pulmonary hypertension in patients with chronic obstructive pulmonary disease: Recent advances in pathophysiology and management
Q Hida et al.
RESPIROLOGY (2002)
Mammalian TOR: A homeostatic ATP sensor
PB Dennis et al.
SCIENCE (2001)
Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
RM Tuder et al.
JOURNAL OF PATHOLOGY (2001)
Pathobiology of pulmonary hypertension - Extracellular matrix
M Rabinovitch
CLINICS IN CHEST MEDICINE (2001)