Journal
FASEB JOURNAL
Volume 26, Issue 10, Pages 4327-4336Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.12-207217
Keywords
thrombospondin 1; cardiovascular risk factors; hypoxia; proliferation; angiogenesis; differentiation
Categories
Funding
- Instituto Salud Carlos III (Madrid, Spain) [SAF2010/16549, CIBERobn-CB06/03, Retic-TERCEL RD06/0010/0017]
- Fundacion Jesus Serra (Barcelona, Spain)
- Instituto Salud Carlos III
- Spanish Ministry of Science and Innovation (MICINN) [RyC-2009-5495]
- Instituto Salud Carlos III, MICINN
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It has been demonstrated that the adipose tissue, a highly functional metabolic tissue, is a reservoir of mesenchymal stem cells. The potential use of adipose-derived stem cells (ADSCs) from white adipose tissue (WAT) for organ repair and regeneration has been considered because of their obvious benefits in terms of accessibility and quantity of available sample. However, the functional capability of ADSCs from subjects with different adiposity has not been investigated. It has been our hypothesis that ADSCs from adipose tissue of patients with metabolic syndrome and high adiposity may be functionally impaired. We report that subcutaneous WAT stromal vascular fraction (SVF) from nonobese individuals had a significantly higher number of CD90(+) cells than SVF from obese patients. The isolated ADSCs from WAT of obese patients had reduced differentiation potential and were less proangiogenic. Therefore, ADSCs in adipose tissue of obese patients have lower capacity for spontaneous or therapeutic repair than ADSCs from nonobese metabolically normal individuals.-Onate, B., Vilahur, G., Ferrer-Lorente, R., Ybarra, J., Diez-Caballero, A., Ballesta-Lopez, C., Moscatiello, F., Herrero, J., Badimon, L. The subcutaneous adipose tissue reservoir of functionally active stem cells is reduced in obese patients. FASEB J. 26, 4327-4336 (2012). www.fasebj.org
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