Journal
FASEB JOURNAL
Volume 25, Issue 4, Pages 1123-1132Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.11-0402ufm
Keywords
immunoglobulin; activation-induced deaminase; somatic hypermutation; B lymphocytes
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Funding
- Medical Research Council [MC_U105178806] Funding Source: Medline
- MRC [MC_U105178806] Funding Source: UKRI
- Medical Research Council [MC_U105178806] Funding Source: researchfish
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The origin of antibody diversity has intrigued scientists for nearly a century. We now know that the diversity is achieved through a 2-stage process. Gene rearrangement (catalyzed by the RAG1/2 recombinase) allows the production of a primary repertoire of antibodies; targeted deamination of cytosines within these rearranged antibody genes (catalyzed by the DNA deaminase AID) then allows them to be further diversified and matured by somatic hypermutation, gene conversion, and class-switch recombination. Here we review the history of the uncovering of some of these processes, contrasting the relative importance of hypothesis and methodological developments in driving the research at different periods of the work.-Ganesh, K., Neuberger, M. S. Unraveling the roles of gene rearrangement and targeted deanimation in antibody gene diversification. FASEB J. 25, 1123-1132 (2011). www.fasebj.org
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