Journal
FAMILY PRACTICE
Volume 30, Issue 4, Pages 404-410Publisher
OXFORD UNIV PRESS
DOI: 10.1093/fampra/cmt010
Keywords
Anxiety; anxiety; disorder; clinical; research; longitudinal; primary care; psychiatry; sleep disorders; substance; abuse (not tobacco)
Categories
Funding
- Dutch Health Care Insurance Council
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Tolerance towards the effects of benzodiazepines is observed in various animal and human studies. Therefore, it is assumed that patients who use benzodiazepines for a longer period of time need to increase their dose over time to experience the same effect. To observe whether long-term benzodiazepine users increase their dose over time. From the Dutch National Information Network of Family Practices, a group of long-term benzodiazepine users was identified. This group was divided into an incident long-term benzodiazepine users group (N 113) and a prevalent long-term benzodiazepine users group (N 992). Long-term use of benzodiazepines was defined as usage for at least 6 months. The main outcome was a change in prescribed dose from baseline until 24 months after baseline. Linear regression analysis was performed to evaluate dose change. Neither incident long-term benzodiazepine users nor prevalent long-term benzodiazepine users were prescribed increasing dosages during follow-up. There is no increase in prescribed dose among long-term users, as might be expected due to the development of tolerance to the effects of benzodiazepines.
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