Journal
EYE
Volume 28, Issue 9, Pages 1100-1106Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/eye.2014.138
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Funding
- Mitsubishi Tanabe Pharma for the Department of Ophthalmology, Kyorin University School of Medicine
- Grants-in-Aid for Scientific Research [26462697, 26462696, 24592678] Funding Source: KAKEN
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Purpose To evaluate the effect of infliximab over the initial 4 years of treatment on inflammatory ocular attacks and background retinal/disc vascular leakage in patients with refractory uveoretinitis associated with Behcet's disease. Methods Clinical records of nine patients were retrospectively reviewed. The main outcomes analyzed were frequency of ocular inflammatory attacks, background retinal and disc vascular leakage as assessed by fluorescein angiography during periods of clinical quiescence, best-corrected visual acuity, and adverse effects. Results The median follow-up on infliximab was 50 months (range 48-58 months). Mean frequency of attacks decreased significantly in years 1, 2, 3, and 4 compared with the baseline 1-year period before infliximab use. Mean background retinal and disc vascular leakage scores also decreased significantly at the end of each 1-year period compared with baseline. Visual acuity improved or was unchanged at the end of 4 years in 17 of 18 eyes. No serious adverse effects were observed. Conclusion Infliximab reduced the mean frequency of ocular attacks and mean background retinal/disc vascular leakage in a long-term sustained manner over 4 years of treatment in Behcet's disease patients.
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