Journal
EXPRESS POLYMER LETTERS
Volume 8, Issue 11, Pages 841-849Publisher
BUDAPEST UNIV TECHNOL & ECON
DOI: 10.3144/expresspolymlett.2014.85
Keywords
biocompatible polymers; polymer synthesis; polymer gels; carboxymethyl cellulose; microfluidic
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Funding
- Basic Research Project of China [2012CB619105]
- National Natural Science Foundation of China [51072056, 51173053]
- Guangdong Natural Science Foundation [9451063201003024]
- Guangdong Provincial Program for Excellent Talents in Universities
- Key Laboratory of Biomaterials of Guangdong Higher Education Institutes of Jinan University
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Biocompatible and biodegradable carboxymethyl cellulose (CMC) has been modified with 4-hydroxybenzylamine (CMC-Ph) in order to prepare CMC-based microgels through the horseradish peroxidise/hydrogen peroxide enzymatic reaction. CMC-Ph was identified as a blend, and the amount of the grafted 4-hydroxybenzylamine per 100 units of CMC was between 17 and 23 according to the molecular weight of CMC. Through a special designed co-flowing microfluidic device, CMC-Ph microgels were prepared with the radius from 100 to 500 mu m via adjusting the flow rates of the disperse phase and the continuous phase, respectively. The chondrocytic cell line ATDC5 was encapsulated in the CMC-Ph microgels. The cell-laden microgels were cultured for up to 40 days, illustrating the biocompatibility of CMC-Ph and the microfluidic approach through the enzymatic crosslinking reaction primarily. CMC-Ph showed a great promise to encapsulate the cells for further fabrication of the injectable scaffolds.
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