4.5 Review

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Insulin X10 revisited: a super-mitogenic insulin analogue

B. F. Hansen et al.

DIABETOLOGIA (2011)

Review Biochemistry & Molecular Biology

Use of mouse models in studying type 2 diabetes mellitus

Angela W. S. Lee et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)

Article Multidisciplinary Sciences

Structure of mammalian AMPK and its regulation by ADP

Bing Xiao et al.

NATURE (2011)

Article Medicine, General & Internal

Everolimus for Advanced Pancreatic Neuroendocrine Tumors.

James C. Yao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Multidisciplinary Sciences

AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner

Jee-Hyun Um et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Tuberous Sclerosis Complex-1 Deficiency Attenuates Diet-Induced Hepatic Lipid Accumulation

Heidi L. Kenerson et al.

PLOS ONE (2011)

Article Endocrinology & Metabolism

Promiscuous affairs of PKB/AKT isoforms in metabolism

Simon M. Schultze et al.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2011)

Article Pathology

The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN Loss

Lina He et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Cell Biology

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

Kyle D. Copps et al.

CELL METABOLISM (2010)

Article Cell Biology

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

Adem Kalender et al.

CELL METABOLISM (2010)

Review Cardiac & Cardiovascular Systems

Oxidative Stress and Diabetic Complications

Ferdinando Giacco et al.

CIRCULATION RESEARCH (2010)

Review Urology & Nephrology

Prospects for mTOR Inhibitor Use in Patients with Polycystic Kidney Disease and Hamartomatous Diseases

Vicente E. Torres et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Endocrinology & Metabolism

Diabetes and Cancer A consensus report

Edward Giovannucci et al.

DIABETES CARE (2010)

Review Pharmacology & Pharmacy

Everolimus: efficacy and safety in cardiac transplantation

S. Allan Schaffer et al.

EXPERT OPINION ON DRUG SAFETY (2010)

Review Pharmacology & Pharmacy

New inhibitors of the mammalian target of rapamycin signaling pathway for cancer

Sebastien Albert et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)

Article Biochemistry & Molecular Biology

Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation

Tomoko Sunami et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

AMPK beta 1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Nicolas Dzamko et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

Gregory R. Steinberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Medicine, Research & Experimental

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

Marc Foretz et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Review Urology & Nephrology

Sirolimus for calcineurin inhibitors in organ transplantation: contra

Paolo Cravedi et al.

KIDNEY INTERNATIONAL (2010)

Article Biochemistry & Molecular Biology

Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass

Francesca Buzzi et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Review Cell Biology

The emerging mechanisms of isoform-specific PI3K signalling

Bart Vanhaesebroeck et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Cell Biology

The nuts and bolts of AGC protein kinases

Laura R. Pearce et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Medicine, General & Internal

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis.

Darcy A. Krueger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Multidisciplinary Sciences

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

Jonathan S. Oakhill et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Paracrinology of islets and the paracrinopathy of diabetes

Roger H. Unger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

Guadalupe Sabio et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Review Physiology

AMP-activated protein kinase: a core signalling pathway in the heart

A. S. Kim et al.

ACTA PHYSIOLOGICA (2009)

Review Endocrinology & Metabolism

Phosphorylation of IRS proteins, insulin action, and insulin resistance

Sigalit Boura-Halfon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Article Endocrinology & Metabolism

Critical roles for the TSC-mTOR pathway in β-cell function

Hiroyuki Mori et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Article Cell Biology

The Akt kinases Isoform specificity in metabolism and cancer

Eva Gonzalez et al.

CELL CYCLE (2009)

Article Cell Biology

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

Karla F. Leavens et al.

CELL METABOLISM (2009)

Article Cell Biology

PIKKing on PKB: regulation of PKB activity by phosphorylation

Lana Bozulic et al.

CURRENT OPINION IN CELL BIOLOGY (2009)

Letter Endocrinology & Metabolism

IRS2 variants and syndromes of severe insulin resistance

W. E. Bottomley et al.

DIABETOLOGIA (2009)

Review Cell Biology

The incretin system and its role in type 2 diabetes mellitus

Jens Juul Holst et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

Article Surgery

Mammalian target of rapamycin inhibitor dyslipidemia in kidney transplant recipients

B. L. Kasiske et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2008)

Review Biochemistry & Molecular Biology

AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism

C. A. Witczak et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Endocrinology & Metabolism

Metformin increases fasting plasma peptide tyrosine tyrosine (PYY) in women with polycystic ovarian syndrome (PCOS)

Tasoula Tsilchorozidou et al.

CLINICAL ENDOCRINOLOGY (2008)

Article Urology & Nephrology

Sirolimus reduces polycystic liver volume in ADPKD patients

Qi Qian et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)

Article Urology & Nephrology

Sirolimus is associated with new-onset diabetes in kidney transplant recipients

Olwyn Johnston et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)

Article Biochemistry & Molecular Biology

Tissue-specific role of glycogen synthase kinase 3β in glucose homeostasis and insulin action

Satish Patel et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Medicine, General & Internal

Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

John J. Bissler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Multidisciplinary Sciences

Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

Latif Rachdi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Immunology

New-onset diabetes mellitus after kidney transplantation: The role of immunosuppression

M. Veroux et al.

TRANSPLANTATION PROCEEDINGS (2008)

Article Biochemistry & Molecular Biology

Genetic deficiency of glycogen synthase kinase-3β corrects diabetes in mouse models of insulin resistance

Katsuya Tanabe et al.

PLOS BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B

Mirela Delibegovic et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Gastroenterology & Hepatology

Molecular and clinical characteristics in 46 families affected with peutz-jeghers syndrome

Hamid Mehenni et al.

DIGESTIVE DISEASES AND SCIENCES (2007)

Review Biochemistry & Molecular Biology

AKT/PKB signaling: Navigating downstream

Brendan D. Manning et al.

Article Medicine, General & Internal

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

Gary Hudes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Medicine, Research & Experimental

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

Yan Shu et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Endocrinology & Metabolism

Metformin prolongs the postprandial fall in plasma ghrelin concentrations in type 2 diabetes

P. J. English et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2007)

Article Immunology

Determinants of insulin resistance in renal transplant recipients

Leendert H. Oterdoom et al.

TRANSPLANTATION (2007)

Review Cell Biology

The two TORCs and Akt

Prashanth T. Bhaskar et al.

DEVELOPMENTAL CELL (2007)

Review Physiology

Peptides targeting protein kinases: Strategies and implications

Oksana Kaidanovich-Beilin et al.

PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport

Mini P. Sajan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Cell Biology

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

Mei-Ling Chen et al.

GENES & DEVELOPMENT (2006)

Review Cell Biology

Lipid droplets: a unified view of a dynamic organelle

S Martin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Review Endocrinology & Metabolism

Mechanisms of Disease: hepatic steatosis in type 2 diabetes - pathogenesis and clinical relevance

Michael Roden

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2006)

Article Biochemistry & Molecular Biology

Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis

JA Kushner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Urology & Nephrology

Glucose metabolism in renal transplant recipients: Effect of calcineurin inhibitor withdrawal and conversion to sirolimus

A Teutonico et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)

Article Medicine, General & Internal

Metformin and reduced risk of cancer in diabetic patients

JMM Evans et al.

BMJ-BRITISH MEDICAL JOURNAL (2005)

Review Medicine, Research & Experimental

Genetic epidemiology of diabetes

MA Permutt et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Cardiac & Cardiovascular Systems

Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome - Natural history

RT Murphy et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)

Article Biochemistry & Molecular Biology

Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

C Kurlawalla-Martinez et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Muscle-specific Pten deletion protects against insulin resistance and diabetes

N Wijesekara et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

SH Koo et al.

NATURE MEDICINE (2004)

Article Biochemistry & Molecular Biology

AMP-activated protein kinase plays a role in the control of food intake

U Andersson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Structure, regulation and function of PKB/AKT - a major therapeutic target

M Hanada et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)

Article Biochemistry & Molecular Biology

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

JM Lizcano et al.

EMBO JOURNAL (2004)

Article Multidisciplinary Sciences

Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity

B Stiles et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Endocrinology & Metabolism

Expression profiling of the γ-subunit isoforms of AMP-activated protein kinase suggests a major role for γ3 in white skeletal muscle

M Mahlapuu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

Article Biochemistry & Molecular Biology

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

JH Feng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Endocrinology & Metabolism

Inhibitor κB kinase is involved in the paracrine crosstalk between human fat and muscle cells

D Dietze et al.

INTERNATIONAL JOURNAL OF OBESITY (2004)

Article Multidisciplinary Sciences

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

U Özcan et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

A family with severe insulin resistance and diabetes due to a mutation in AKT2

S George et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Targets for TNF-α-induced lipolysis in human adipocytes

M Rydén et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Biochemistry & Molecular Biology

C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase

EK Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

The AMP-activated protein kinase cascade - a unifying system for energy control

D Carling

TRENDS IN BIOCHEMICAL SCIENCES (2004)

Article Biochemistry & Molecular Biology

Protein kinase Bα/Akt1 regulates placental development and fetal growth

ZZ Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Endocrinology & Metabolism

IRS proteins and the common path to diabetes

MF White

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2002)

Article Endocrinology & Metabolism

PKC-ζ mediates insulin effects on glucose transport in cultured preadipocyte-derived human Adipocytes

G Bandyopadhyay et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)

Review Biochemistry & Molecular Biology

Ten years of protein kinase B signalling: a hard Akt to follow

DP Brazil et al.

TRENDS IN BIOCHEMICAL SCIENCES (2001)

Article Biochemistry & Molecular Biology

Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

H Cho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Medicine, Research & Experimental

Role of AMP-activated protein kinase in mechanism of metformin action

GC Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Biochemistry & Molecular Biology

MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro

G Roth et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)