4.5 Article

The Nrf2-ARE cytoprotective pathway in astrocytes

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

Marcus J. Calkins et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Article Biochemistry & Molecular Biology

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

C. J. Harvey et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Multidisciplinary Sciences

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

Pei-Chun Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Pharmacology & Pharmacy

Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections

Antonio Cuadrado et al.

CURRENT PHARMACEUTICAL DESIGN (2008)

Article Biochemistry & Molecular Biology

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

J. van Horssen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Biochemistry & Molecular Biology

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Rosa Resende et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Review Biochemistry & Molecular Biology

Nrf2-induced antioxidant Protection: A Promising target to counteract ROS-mediated damage in neurodegenerative disease?

Helga E. de Vries et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Immunology

The transcription factor Nrf2 is a therapeutic target against brain inflammation

Nadia G. Innamorato et al.

JOURNAL OF IMMUNOLOGY (2008)

Review Immunology

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

Solomon S. Shaftel et al.

JOURNAL OF NEUROINFLAMMATION (2008)

Article Clinical Neurology

Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis

Alexander Sarlette et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

Article Biochemistry & Molecular Biology

Physiological significance of reactive cysteine residues of keap1 in determining Nrf2 activity

Tae Yamamoto et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Neurosciences

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Katja Kanninen et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2008)

Review Neurosciences

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

Lars Bertram et al.

NATURE REVIEWS NEUROSCIENCE (2008)

Review Biochemistry & Molecular Biology

Insights into amyloid-β-induced mitochondrial dysfunction in Alzheimer disease

Xinglong Wang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Review Biochemistry & Molecular Biology

Parkinson's disease

Bobby Thomas et al.

HUMAN MOLECULAR GENETICS (2007)

Article Cell Biology

Subcellular localization and cytoplasmic complex status of endogenous Keap1

Yoriko Watai et al.

GENES TO CELLS (2007)

Article Biochemistry & Molecular Biology

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

Zheng Sun et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Role of Nrf2 in protection against intracerebral hemorrhage injury in mice

Jian Wang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Article Neurosciences

Nrf2--mediated protection against 6-hydroxydopamine

Rebekah J. Jakel et al.

BRAIN RESEARCH (2007)

Article Biochemistry & Molecular Biology

Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress - Relevance to Parkinson disease

Noriyuki Yamamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Clinical Neurology

Expression of Nrf2 in neurodegenerative diseases

Chenere P. Ramsey et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)

Review Physiology

Nitric oxide and peroxynitrite in health and disease

Pal Pacher et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Neurosciences

In vivo modulation of the Parkinsonian phenotype by Nrf2

Neal C. Burton et al.

NEUROTOXICOLOGY (2006)

Review Biochemistry & Molecular Biology

Oxidative damage in Huntington's disease pathogenesis

Susan E. Browne et al.

ANTIOXIDANTS & REDOX SIGNALING (2006)

Article Biochemistry & Molecular Biology

Mitochondrial glutathione transport: Physiological, pathological and toxicological implications

Lawrence H. Lash

CHEMICO-BIOLOGICAL INTERACTIONS (2006)

Article Multidisciplinary Sciences

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

David R. Beers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Multidisciplinary Sciences

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Michael T. Lin et al.

NATURE (2006)

Article Multidisciplinary Sciences

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Casey M. Clements et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Pharmacology & Pharmacy

Transport of glutathione and glutathione conjugates by MRP1

Susan P. C. Cole et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2006)

Article Multidisciplinary Sciences

Onset and progression in inherited ALS determined by motor neurons and microglia

Severine Boillee et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis

MR Vargas et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Medicine, Research & Experimental

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

RK Thimmulappa et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Cell Biology

Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia

W Song et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

Article Geriatrics & Gerontology

Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

HM Schipper et al.

NEUROBIOLOGY OF AGING (2006)

Article Multidisciplinary Sciences

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers

T Satoh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biochemistry & Molecular Biology

Oxidative stress and neurodegeneration: where are we now?

Barry Halliwell

JOURNAL OF NEUROCHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Nrf2, a multi-organ protector?

JM Lee et al.

FASEB JOURNAL (2005)

Article Biochemistry & Molecular Biology

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo

AY Shih et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

M Velichkova et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Neurosciences

The Nrf2-ARE Signalling Pathway: Promising Drug Target to Combat Oxidative Stress in Neurodegenerative Disorders

Freek L. van Muiswinkel et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)

Article Multidisciplinary Sciences

Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription

MJ Calkins et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Neurosciences

Peroxide detoxification by brain cells

R Dringen et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2005)

Article Multidisciplinary Sciences

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

JH Suh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

N Wakabayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase

SB Cullinan et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Cell Biology

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

J Li et al.

PHYSIOLOGICAL GENOMICS (2004)

Article Biochemistry & Molecular Biology

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2

A Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Heme oxygenase expression in human central nervous system disorders

HM Schipper

FREE RADICAL BIOLOGY AND MEDICINE (2004)

Article Biochemistry & Molecular Biology

Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury

YS Ho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Neurosciences

A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis

LH Barbeito et al.

BRAIN RESEARCH REVIEWS (2004)

Review Cell Biology

Brain iron deposition and the free radical-mitochondrial theory of ageing

HM Schipper

AGEING RESEARCH REVIEWS (2004)

Article Geriatrics & Gerontology

Regional NAD(P)H : quinone oxidoreductase activity in Alzheimer's disease

KS SantaCruz et al.

NEUROBIOLOGY OF AGING (2004)

Review Neurosciences

Unraveling the mechanisms involved in motor neuron degeneration in ALS

LI Bruijn et al.

ANNUAL REVIEW OF NEUROSCIENCE (2004)

Article Geriatrics & Gerontology

Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra

FL van Muiswinkel et al.

NEUROBIOLOGY OF AGING (2004)

Article Multidisciplinary Sciences

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

EM Valente et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts

A Hayashi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Biochemistry & Molecular Biology

EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice

A Hirayama et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Article Physiology

Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2

J Alam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)

Article Biochemistry & Molecular Biology

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

D Stewart et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Genetics & Heredity

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

N Wakabayashi et al.

NATURE GENETICS (2003)

Article Medicine, Research & Experimental

Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

H Ischiropoulos et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Biochemistry & Molecular Biology

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

H Sasaki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

AT Dinkova-Kostova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

DS Howland et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

MB Bogdanov et al.

JOURNAL OF NEUROCHEMISTRY (2001)

Article Neurosciences

Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons

R Dringen et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2001)

Review Neurosciences

Superoxide dismutase and the death of motoneurons in ALS

JS Beckman et al.

TRENDS IN NEUROSCIENCES (2001)

Review Neurosciences

From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS

DW Cleveland et al.

NATURE REVIEWS NEUROSCIENCE (2001)

Article Urology & Nephrology

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

K Yoh et al.

KIDNEY INTERNATIONAL (2001)

Article Multidisciplinary Sciences

Neural roles for heme oxygenase:: Contrasts to nitric oxide synthase

DE Barañano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Review Medicine, General & Internal

Medical progress: Amyotrophic lateral sclerosis.

LP Rowland et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Article Biochemistry & Molecular Biology

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

JY Chan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2000)

Review Neurosciences

Metabolism and functions of glutathione in brain

R Dringen

PROGRESS IN NEUROBIOLOGY (2000)

Article Biochemistry & Molecular Biology

Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death

K Chen et al.

JOURNAL OF NEUROCHEMISTRY (2000)