Related references
Note: Only part of the references are listed.The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease
Marcus J. Calkins et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
C. J. Harvey et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
Pei-Chun Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections
Antonio Cuadrado et al.
CURRENT PHARMACEUTICAL DESIGN (2008)
Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression
J. van Horssen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
Rosa Resende et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Nrf2-induced antioxidant Protection: A Promising target to counteract ROS-mediated damage in neurodegenerative disease?
Helga E. de Vries et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
The transcription factor Nrf2 is a therapeutic target against brain inflammation
Nadia G. Innamorato et al.
JOURNAL OF IMMUNOLOGY (2008)
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
Takumi Satoh et al.
JOURNAL OF NEUROCHEMISTRY (2008)
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
Solomon S. Shaftel et al.
JOURNAL OF NEUROINFLAMMATION (2008)
Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis
Alexander Sarlette et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis
Marcelo R. Vargas et al.
JOURNAL OF NEUROSCIENCE (2008)
Physiological significance of reactive cysteine residues of keap1 in determining Nrf2 activity
Tae Yamamoto et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Katja Kanninen et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2008)
Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation
Christoph J. Wruck et al.
MOLECULAR PHARMACOLOGY (2008)
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Koji Yamanaka et al.
NATURE NEUROSCIENCE (2008)
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Lars Bertram et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Insights into amyloid-β-induced mitochondrial dysfunction in Alzheimer disease
Xinglong Wang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2007)
Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage
Xiurong Zhao et al.
STROKE (2007)
Parkinson's disease
Bobby Thomas et al.
HUMAN MOLECULAR GENETICS (2007)
Subcellular localization and cytoplasmic complex status of endogenous Keap1
Yoriko Watai et al.
GENES TO CELLS (2007)
Enhancing expression of Nrf2-driven genes protects the blood-brain barrier after brain injury
Jing Zhao et al.
JOURNAL OF NEUROSCIENCE (2007)
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
Zheng Sun et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Activation of the Nrf2-ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1
Andrew D. Kraft et al.
EXPERIMENTAL NEUROLOGY (2007)
Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS
Laura Ferraiuolo et al.
JOURNAL OF NEUROSCIENCE (2007)
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice
Jian Wang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2007)
Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis
Mariana Pehar et al.
JOURNAL OF NEUROSCIENCE (2007)
Nrf2--mediated protection against 6-hydroxydopamine
Rebekah J. Jakel et al.
BRAIN RESEARCH (2007)
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Makiko Nagai et al.
NATURE NEUROSCIENCE (2007)
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress - Relevance to Parkinson disease
Noriyuki Yamamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Expression of Nrf2 in neurodegenerative diseases
Chenere P. Ramsey et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
Nitric oxide and peroxynitrite in health and disease
Pal Pacher et al.
PHYSIOLOGICAL REVIEWS (2007)
In vivo modulation of the Parkinsonian phenotype by Nrf2
Neal C. Burton et al.
NEUROTOXICOLOGY (2006)
Oxidative damage in Huntington's disease pathogenesis
Susan E. Browne et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Mitochondrial glutathione transport: Physiological, pathological and toxicological implications
Lawrence H. Lash
CHEMICO-BIOLOGICAL INTERACTIONS (2006)
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
David R. Beers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin et al.
NATURE (2006)
Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation
Andy Y. Shih et al.
JOURNAL OF NEUROSCIENCE (2006)
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
Casey M. Clements et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism - A two-site interaction model for the Nrf2-Keap1 complex
Michael McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Transport of glutathione and glutathione conjugates by MRP1
Susan P. C. Cole et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface
Xiaojian Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Onset and progression in inherited ALS determined by motor neurons and microglia
Severine Boillee et al.
SCIENCE (2006)
Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
MR Vargas et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Retrovirus-induced oxidative stress with neuroimmunodegeneration is suppressed by antioxidant treatment with a refined monosodium α-luminol (Galavit)
YH Jiang et al.
JOURNAL OF VIROLOGY (2006)
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
RK Thimmulappa et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses
WN Qiang et al.
JOURNAL OF VIROLOGY (2006)
The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes
T Minich et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia
W Song et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Astrocytes induce hemeoxygenase-1 expression in microglia: A feasible mechanism for preventing excessive brain inflammation
KJ Min et al.
JOURNAL OF NEUROSCIENCE (2006)
Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
HM Schipper et al.
NEUROBIOLOGY OF AGING (2006)
Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
J Zhao et al.
NEUROSCIENCE LETTERS (2006)
Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers
T Satoh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Oxidative stress and neurodegeneration: where are we now?
Barry Halliwell
JOURNAL OF NEUROCHEMISTRY (2006)
Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury
J Zhao et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo
AY Shih et al.
JOURNAL OF NEUROSCIENCE (2005)
Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
T Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes
MR Vargas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Nrf2, a multi-organ protector?
JM Lee et al.
FASEB JOURNAL (2005)
Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
AY Shih et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism
M Velichkova et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Mitochondrial dysfunction and its role in motor neuron degeneration in ALS
G Manfredi et al.
MITOCHONDRION (2005)
Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity
ME Gegg et al.
BRAIN RESEARCH (2005)
The Nrf2-ARE Signalling Pathway: Promising Drug Target to Combat Oxidative Stress in Neurodegenerative Disorders
Freek L. van Muiswinkel et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)
Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
MJ Calkins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Peroxide detoxification by brain cells
R Dringen et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
Astrocytic production of nerve growth factor in motor neuron apoptosis:: implications for amyotrophic lateral sclerosis
M Pehar et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
JH Suh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
AL Levonen et al.
BIOCHEMICAL JOURNAL (2004)
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
AD Kraft et al.
JOURNAL OF NEUROSCIENCE (2004)
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
J Li et al.
PHYSIOLOGICAL GENOMICS (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Heme oxygenase expression in human central nervous system disorders
HM Schipper
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury
YS Ho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
LH Barbeito et al.
BRAIN RESEARCH REVIEWS (2004)
Brain iron deposition and the free radical-mitochondrial theory of ageing
HM Schipper
AGEING RESEARCH REVIEWS (2004)
Regional NAD(P)H : quinone oxidoreductase activity in Alzheimer's disease
KS SantaCruz et al.
NEUROBIOLOGY OF AGING (2004)
Unraveling the mechanisms involved in motor neuron degeneration in ALS
LI Bruijn et al.
ANNUAL REVIEW OF NEUROSCIENCE (2004)
Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra
FL van Muiswinkel et al.
NEUROBIOLOGY OF AGING (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Mitochondrial Iron Sequestration in Dopamine-Challenged Astroglia: Role of Heme Oxygenase-1 and the Permeability Transition Pore
H. M. Schipper et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels
N Morito et al.
ONCOGENE (2003)
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts
A Hayashi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice
A Hirayama et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
JM Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
J Alam et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells
KU Kotlo et al.
ONCOGENE (2003)
Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
D Stewart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
N Wakabayashi et al.
NATURE GENETICS (2003)
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
H Ischiropoulos et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death
B Fauconneau et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression
H Sasaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Motoneuron death triggered by a specific pathway downstream of Fas:: Potentiation by ALS-linked SOD1 mutations
C Raoul et al.
NEURON (2002)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
S Braun et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
SA Chanas et al.
BIOCHEMICAL JOURNAL (2002)
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
H Motohashi et al.
GENE (2002)
Involvement of amino-acid side chains of membrane proteins in the binding of glutathione to pig cerebral cortical membranes
A Hermann et al.
NEUROCHEMICAL RESEARCH (2002)
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
DS Howland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease
MB Bogdanov et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons
R Dringen et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2001)
Superoxide dismutase and the death of motoneurons in ALS
JS Beckman et al.
TRENDS IN NEUROSCIENCES (2001)
From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
DW Cleveland et al.
NATURE REVIEWS NEUROSCIENCE (2001)
Nrf2-deficient female mice develop lupus-like autoimmune nephritis
K Yoh et al.
KIDNEY INTERNATIONAL (2001)
Neural roles for heme oxygenase:: Contrasts to nitric oxide synthase
DE Barañano et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis
K Mehindate et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Medical progress: Amyotrophic lateral sclerosis.
LP Rowland et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress
J Hirrlinger et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
JY Chan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2000)
Metabolism and functions of glutathione in brain
R Dringen
PROGRESS IN NEUROBIOLOGY (2000)
NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Alzheimer's disease
YX Wang et al.
NEUROBIOLOGY OF AGING (2000)
Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death
K Chen et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Heme oxygenase-1 induction protects murine cortical astrocytes from hemoglobin toxicity
RF Regan et al.
NEUROSCIENCE LETTERS (2000)