Journal
EXPERT REVIEW OF VACCINES
Volume 14, Issue 1, Pages 21-35Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2015.955478
Keywords
Brugia malayi; computational vaccinology; EID; EpiMatrix; filarial; immunogenicity; immunoinformatics; immunomics; JanusMatrix; MHC; NTD; T cell; TCR; tregitope
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Funding
- National Institutes of Health Research [U19 AI082642]
- NIH/NIAID Filariasis Research Reagent Resource Center
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Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world's poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.
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