Journal
EXPERT REVIEW OF VACCINES
Volume 11, Issue 11, Pages 1347-1354Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.12.105
Keywords
G2P[4]; G3P[8]; genotype; relative enrichment; Rotarix (R); RotaTeq (R); rotavirus; selective pressure; vaccine
Categories
Funding
- 'Fonds voor Wetenschappelijk Onderzoek' postdoctoral fellowship
- National Health and Medical Research Council CDA fellowship [609347]
- GlaxoSmithKline Biologicals
- CSL
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Expert Rev. Vaccines 11(11), 1347-1354 (2012) Two human group A rotavirus (RVA) vaccines are available and highly effective in preventing severe gastroenteritis caused by all commonly circulating human RVA genotypes. The effect of universal mass vaccination on the RVA genotype distribution is discussed based on the knowledge of complete RVA genotype constellations, data from clinical efficacy trials and effectiveness studies, and genotype surveillance data from countries with universal mass vaccination programs. The theoretically predicted relative enrichment of RVA strains with the G2P[4] DS-1-like genotype constellation in regions with high coverage by Rotarix (R) (GlaxoSmithKline Biologicals, Rixensart, Belgium) seems to become apparent. A G3P[8] genotype increase, which was noted in several regions with a high coverage of RotaTeq (R) (Merck and Co., Inc., NJ, USA), is more difficult to explain based on the theoretical considerations.
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