Journal
EXPERT REVIEW OF VACCINES
Volume 11, Issue 6, Pages 695-719Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.12.38
Keywords
2,2 '-dithiodipyridine; beta-propiolactone; binary ethylene imine; formaldehyde; gamma irradiation; glutaraldehyde; pH; temperature; UV; vaccine; virus inactivation
Categories
Funding
- Institute for the Promotion of Innovation by Science and Technology in Flanders [IWT-LO 040721]
- Ghent University [BOF-01J06111]
- EU [245141]
Ask authors/readers for more resources
The aim of this review is to make researchers aware of the benefits of an efficient quality control system for prediction of a developed vaccine's efficacy. Two major goals should be addressed when inactivating a virus for vaccine purposes: first, the infectious virus should be inactivated completely in order to be safe, and second, the viral epitopes important for the induction of protective immunity should be conserved after inactivation in order to have an antigen of high quality. Therefore, some problems associated with the virus inactivation process, such as virus aggregate formation, protein crosslinking, protein denaturation and degradation should be addressed before testing an inactivated vaccine in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available