Journal
EXPERT REVIEW OF VACCINES
Volume 9, Issue 2, Pages 137-147Publisher
EXPERT REVIEWS
DOI: 10.1586/ERV.09.139
Keywords
Cuba; dengue; domain III; envelope; Neisseria meningitidis; p64k protein; vaccine
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A dengue vaccine should induce long-lasting, simultaneous protection to the four dengue viruses while avoiding the immune enhancement of viral infection. Domain III of the dengue envelope protein has been implicated in receptor binding, and is also the target of specific neutralizing antibodies. Domain III has emerged as a promising region for a subunit vaccine candidate. Here, we review the current state of knowledge on vaccine candidates based on domain III. Due to the results obtained concerning the immune response and protection in mice and monkeys, particular attention is paid to the chimeric protein domain III fused to p64k of Neisseria meningitidis.
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