Journal
EXPERT REVIEW OF VACCINES
Volume 8, Issue 11, Pages 1565-1573Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.09.121
Keywords
HBcAg; HBV subunit vaccine platform; virus-like particle; WHcAg
Categories
Funding
- NIAID NIH HHS [R43 AI072785, R01 AI049730-08, R43 AI072785-02, R01 AI049730, R01 AI020720, R01 AI020720-27] Funding Source: Medline
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The first virus-like particle to be tested for use as a vaccine carrier was based on the hepatitis B virus nucleocapsid protein. This viral subunit, while not infectious on its own, is a 36-nm particle that is highly immunogenic during a natural infection. The self-assembly and high degree of immunogenicity is maintained when expressed as a recombinant protein and, moreover, can confer a high degree of immunogenicity on foreign antigens linked to the particle, either chemically or genetically. This review describes the current state of the hepadnaviral core protein as a vaccine carrier.
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