Journal
EXPERT REVIEW OF VACCINES
Volume 8, Issue 5, Pages 625-645Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.09.21
Keywords
adjuvant; animal model; Campylobacter jejuni; CWC whole-cell vaccine; immunological host response; pathogen interaction with eukaryotic cells; subunit vaccine
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Funding
- Ministry of Science and Higher Education [N303 110 3113970]
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Campylobacteriosis constitutes a serious medical and socioeconomic problem worldwide. Rapidly increasing antibiotic resistance of bacterial strains compels us to develop alternative therapeutic strategies and to search for efficient immunoprophylactic methods. The vast majority of Campylobacter infections in developed countries occur as sporadic cases, mainly caused by eating undercooked Campylobacter-contaminated poultry. The most efficient strategy of decreasing the number of human Campylobacter infections is by implementing protective vaccinations for humans and/or chickens. Despite more than 10 years of research, an effective anti-Campylobacter vaccine has not been developed. This review highlights our increasing knowledge of Campylobacter interaction with host cells and focuses on recently published data describing the efficacy of anti-Campylobacter vaccine prototypes.
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