Journal
EXPERT REVIEW OF VACCINES
Volume 8, Issue 5, Pages 577-592Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.09.14
Keywords
DNA; heterologous prime-boost immunization; HIV/AIDS; malaria; protein; tuberculosis; viral vector
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Classical vaccination approaches, based on a single vaccine administered in a homologous prime-boost schedule and optimized to induce primarily neutralizing antibodies, are unlikely to be sufficiently efficacious to prevent TB, malaria or HIV infections. Novel vaccines, capable of inducing a more powerful immune response, in particular T-cell immunity, are desperately needed. Combining different vaccine modalities that are able to complement each other and induce broad and sustainable immunity is a promising approach. This review provides an overview of heterologous prime-boost vaccination modalities currently in development for the 'big three' poverty-related diseases and emphasizes the need for innovative vaccination approaches.
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