Journal
EXPERT REVIEW OF PROTEOMICS
Volume 11, Issue 4, Pages 449-463Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.2014.905743
Keywords
biomarker; colorectal cancer; plasma; serum; shotgun proteomics; targeted proteomics
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Funding
- Institute for Promotion of Innovation through Science and Technology in Flanders (IWT) [IM110568]
- Emmanuel Van der Schueren grant of Vlaamse Liga tegen kanker (VLK)
- Flemish Institute for Technological Research (VITO)
- Industrial Research Fund (KU Leuven)
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Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, efforts have been undertaken to identify candidate diagnostic CRC markers in plasma and serum. In this review, the challenges, bottlenecks and promising properties of mass spectrometry (MS)-based proteomics in blood are discussed. More specifically, important aspects in clinical design, sample retrieval, sample preparation, and MS analysis are presented. The recent developments in targeted MS approaches in plasma or serum are highlighted as well.
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