Journal
EXPERT REVIEW OF PROTEOMICS
Volume 9, Issue 2, Pages 149-163Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.12.13
Keywords
biomarker; cancer early detection; cancer screening; cervical cancer; diagnostic accuracy; HPV E6; HPV E7; human papillomavirus; p16(INK4a); viral oncogenes
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Biomarkers indicating the initiation of neoplastic transformation processes in human papillomavirus (HPV)-infected epithelial cells are moving into the focus of cancer prevention research, particularly for anogenital cancer, including cancer of the uterine cervix. Based on the in-depth understanding of the molecular events leading to neoplastic transformation of HPV-infected human cells, the cyclin-dependent kinase inhibitor p16(INK4a) turned out to be substantially overexpressed in virtually all HPV-transformed cells. This finding opened novel avenues in diagnostic histopathology to substantially improve the diagnostic accuracy of cervical cancer and its precursor lesions. Furthermore, it provides a novel technical platform to substantially improve the accuracy of cytology-based cancer early-detection programs. Here, we review the molecular background and the current evidence for the clinical utility of the p16(INK4a) biomarker for HPV-related cancers, and cervical cancer prevention in particular.
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