Journal
EXPERT REVIEW OF PROTEOMICS
Volume 8, Issue 6, Pages 759-774Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.11.63
Keywords
mass spectrometry; poly(ADP-ribose); poly(ADP-ribose) polymerase-1; post-translational modification; proteomics
Categories
Funding
- Canada research chair in proteomics
- Canadian Institute of Health Research (CIHR) [MOP-17803]
- Fonds de la Recherche en Sante du Quebec
- Cancer Research Society
Ask authors/readers for more resources
PARP-1 is an abundant nuclear protein that plays an essential role in the regulation of many genome integrity and chromatin-based processes, such as DNA repair, replication or transcriptional regulation. PARP-1 modulates the function of chromatin and nuclear proteins through several poly(ADP-ribose) (pADPr)-dependent pathways. Aside from the clearly established role of PARP-1 in the maintenance of genome stability, PARP-1 also emerged as an important regulator that links chromatin functions with extranuclear compartments. pADPr signaling has notably been found to be responsible for PARP-1-mediated mitochondrial dysfunction and cell death. Defining the mechanisms that govern the intrinsic functions of PARP-1 is fundamental to the understanding of signaling networks regulated by pADPr. The emergence of mass spectrometry-based proteomics and its broad applications in the study of biological systems represents an outstanding opportunity to widen our knowledge of the functional spectrum of PARP-1. In this article, we summarize various PARP-1 targeted proteomics studies and proteome-wide analyses that shed light on its protein interaction partners, expression levels and post-translational modifications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available