Journal
EXPERT REVIEW OF PROTEOMICS
Volume 7, Issue 6, Pages 927-941Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.10.83
Keywords
biomarker discovery; clinical proteomics; MALDI imaging; MALDI imaging mass spectrometry; molecular pathology; personalized medicine; tissue analysis
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Funding
- Federal Ministry of Education and Research (BMBF) Germany [01EZ0803, 0315508A]
- German Research Foundation (DFG) [SFB 824]
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MALDI imaging mass spectrometry ('MALDI imaging') is an increasingly recognized technique for biomarker research. After years of method development in the scientific community, the technique is now increasingly applied in clinical research. In this article, we discuss the use of MALDI imaging in clinical proteomics and put it in context with classical proteomics techniques. We also highlight a number of upcoming challenges for personalized medicine, development of targeted therapies and diagnostic molecular pathology where MALDI imaging could help.
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