Journal
EXPERT REVIEW OF PROTEOMICS
Volume 6, Issue 6, Pages 631-645Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.09.82
Keywords
cross-reactivity; glycan array; glycomics; high-throughput evaluation; mass spectrometry; mixed-ligand array; multivalent
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Funding
- Academia Sinica, Taiwan and National Science Council, Taiwan [NSC 97-2113-M-001-009-MY2]
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Glycan arrays have become a powerful tool for the high-throughput elucidation of interactions of different carbohydrate structures with a wide variety of biological targets, including antibodies, proteins, viruses and cells. This technique is especially suitable for glycomics studies, because arrays present carbohydrate ligands in a manner that mimics interactions at cell-cell interfaces. This review assesses the recent advances involving glycan arrays, including new methods for glycan-array fabrication, new platforms for novel biological information, and new perceptions of glycomics for improving the understanding of disease-related glycobiology. Furthermore, this review attempts to forecast trends in the development of glycan arrays and possible solutions for some remaining challenges to improve this new technology.
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