Journal
EXPERT REVIEW OF PROTEOMICS
Volume 5, Issue 2, Pages 283-291Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.5.2.283
Keywords
biomarker discovery; biomarkers; diagnosis; plasma and serum; proteomics; traumatic brain injury; validation
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Funding
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
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Iraq and Afghanistan has brought this disorder to the attention of the global community. A biomarker that would enable army medics to rapidly diagnose the severity of TBI on the battlefield would be a huge asset. Unfortunately, the study of TBI has not historically attracted the proteomic research community's interest as other disorders have, such as cancer. On the positive side, however, many of the analytical and technological challenges that were overcome in the development of biofluid proteomic methods are now being applied to the study of TBI. In this review, we discuss and highlight select examples of discovery-driven proteomic studies focused on finding effective biomarkers for TBI.
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