Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 14, Issue 11, Pages 1293-1306Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737175.2014.964211
Keywords
glioblastoma; neurotherapeutics; NF-B; signaling; STAT3
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Funding
- National Institutes of Health [R01CA138517, R01NS057563, R01NS050665]
- American Brain Tumor Association Basic Research Fellowship in Honor of Paul Fabbri
- William E. Cash Jr. Memorial Fund in Neuro-Oncology Research
- UAB Comprehensive Cancer Center
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Since we last addressed the roles of NF-B and JAK/STAT3 signaling in glioblastoma (GBM) 5 years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance and treatment resistance, both NF-B and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in the molecular understanding of GBM, the structure of NF-B and STAT3 signaling, the ways in which these pathways contribute to GBM and advances in preclinical and clinical targeting of these two signaling cascades.
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