Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 13, Issue 7, Pages 747-750Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737175.2013.811191
Keywords
auditory sensory gating; dopamine; microglial activation; peripubertal stress; prenatal immune activation; schizophrenia; two-hit model
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [24659143] Funding Source: KAKEN
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Epidemiological studies show that maternal viral infection during pregnancy plays a key role in the etiology of neurodevelopmental disorders, such as schizophrenia and autism. Prenatal maternal immune activation and peripubertal psychological stress are key environmental risk factors for neurodevelopmental disorders. Viral mimic polyriboinosinic-polyribocytidylic acid is known to act as a Toll-like receptor-3 agonist. Polyriboinosinic-polyribocytidylic acid has been typically used to establish this rodent model of prenatal immune activation. Recently, Giovanoli et al. reported on a new neurodevelopmental model of schizophrenia based on combined prenatal immune activation and peripubertal stress. In this report, we place these findings into context and discuss their significance.
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