Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 11, Issue 8, Pages 1107-1110Publisher
EXPERT REVIEWS
DOI: 10.1586/ERN.11.80
Keywords
awake surgery; epilepsy; intraoperative electrical mapping; low-grade glioma; MRI
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Funding
- Novartis
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Seizures are often the presenting symptoms of a cerebral tumor and may precede its diagnosis by many years. The article under evaluation searched two large English registries for patients admitted for new-onset epilepsy. The risk of subsequently being diagnosed with a malignant brain tumor was found to be 26-fold higher compared with controls, persisted over many years and was accentuated in young patients. Recently, surgical advances have led to a significant decrease in surgical morbidities, making surgery the first treatment option for gliomas, especially low-grade gliomas. This paradigm shift warrants a consequent diagnostic workup (MRI) in patients at risk for low-grade glioma that is, patients with new-onset epilepsy. The study is discussed in the context of the ongoing debate on neuroimaging after new-onset epilepsy.
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