Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 10, Issue 7, Pages 1209-1218Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.10.84
Keywords
Alzheimer's disease; autophagy; death; neurodegeneration; protection; therapeutic target
Categories
Funding
- Anavex
- Canopus BioPharma
- Medivation
- Neurotez
- Neuropharm
- Panacea Pharmaceuticals
- Voyager Pharmaceuticals
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Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated proteins in cells. Extensive literature exists supporting a causative role of mitochondrial dysfunction and amyloid-beta protein in the pathogenesis of Alzheimer's disease (AD). Furthermore, a link between mitochondrial dysfunction, amyloid-beta levels and autophagy has been reported to occur in AD. However, it is not yet clear if autophagy plays a causative role, a protective role or is a consequence of the disease process itself. Understanding the exact role of autophagy in different stages of AD progression may help to design more effective therapeutic strategies. A central issue in developing therapies for neurodegenerative diseases involves understanding why and when responses to stress or injury can help prevent neuronal degeneration and death.
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