Journal
EXPERT REVIEW OF MEDICAL DEVICES
Volume 10, Issue 4, Pages 501-507Publisher
EXPERT REVIEWS
DOI: 10.1586/17434440.2013.811834
Keywords
allograft; bowel replacement; colon tissue; rectal tissue; scaffold; tissue engineering
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Funding
- Fondation pour l'Avenir in the program of Recherche Medical Appliquee
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Gastrointestinal tissue engineering has emerged over the past 20 years and was often focused on esophagus, stomach or small intestine, whereas bioengineering researches of colorectal tissue are scarce. However, some promising results have been obtained in animal models. Refinements should be performed in scaffold and cell source selection to allow smooth muscle layer regeneration. Indeed, synthetic and natural polymers such as small intestinal submucosa and collagen sponge seeded with organoid units or smooth muscle cells did not allow smooth muscle regeneration. Mesenchymal stem cells derived from adipose tissue seeded on composite scaffold could represent an interesting way to achieve this goal. This article reviews potential indications, current status and perspectives of tissue engineering in the area of colorectal surgery.
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