Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 14, Issue 9, Pages 731-737Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2018.1512407
Keywords
Chronic rhinosinusitis; nasal polyps; epithelium; immunology; inflammation
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Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common and quality-of-life impacting disorder, with an underlying immunological mechanism similar to other conditions such as eosinophilic asthma or atopic eczema. Areas covered: This review article summarizes the most recent evidence on the main immunological mechanisms involved in the pathogenesis and the perpetuation of CRSwNP, with a particular focus on the key role of epithelium-derived inflammation as a consequence of the interaction with the airborne environment. Expert commentary: The increase in knowledge of the immunology of CRSwNP leads to the development of therapeutical strategies based upon the use of biologic agents that, according to a personalized and precision medicine approach, will provide each single patient with the most suitable immunological treatment.
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