Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 14, Issue 10, Pages 817-829Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2018.1519396
Keywords
Primary Sjogren's syndrome; interferons; pathogenesis; treatment; stratification; biomarker
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Funding
- Dutch Arthritis Foundation (Reumafonds) [14-3-404]
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Introduction: Primary Sjogren's syndrome (pSS) is one of the most common systemic autoimmune diseases. At the moment, there is no cure for this disease and its etiopathology is complex. Interferons (IFNs) play an important role in the pathogenesis of this disease and are a potential treatment target. Areas covered: Here we discuss the role of IFNs in pSS pathogenesis, complications encountered upon studying IFN-induced gene expression, and comment on the current knowledge on easy clinical applicable 'IFN signatures'. The current treatment options targeting IFNs in pSS are summarized and the perspective of potential new strategies discussed. Expert commentary: The authors provide their perspective on the role of IFNs in pSS and how this knowledge could be used to improve pSS diagnosis, provide new treatment targets, to monitor clinical trials and to stratify pSS patients in order to move toward precision medicine.
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