Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 10, Issue 11, Pages 1463-1474Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2014.967684
Keywords
asthma; atopy; eczema; Eosinophilic esophagitis; TSLP; TSLP-R
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Funding
- NIAID NIH HHS [K08 AI089982] Funding Source: Medline
- NIDDK NIH HHS [R01 DK087789] Funding Source: Medline
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Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine similar to IL-7, whose gene is located on chromosome 5q22.1 and it exerts its biological function through the TSLP-Receptor (TSLP-R). TSLP is expressed primarily by epithelial cells at barrier surfaces such as the skin, gut and lung in response to danger signals. Since it was cloned in 1994, there has been accumulating evidence that TSLP is crucial for the maturation of antigen presenting cells and hematopoietic cells. TSLP genetic variants and its dysregulated expression have been linked to atopic diseases such as atopic dermatitis, asthma, allergic rhinitis and eosinophilic esophagitis.
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