Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 10, Issue 5, Pages 573-582Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2014.893827
Keywords
tyrosine kinase inhibitor; tyrosine kinase; apoptotic cell clearance; systemic lupus erythematosus
Categories
Funding
- NIAID [U19AI10822726]
- NIDDK [1K01DK095067]
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The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear antigens. Breakdown of tolerance is associated with alterations in T-cell and B-cell receptor signal transduction, including increased protein phosphorylation that may underlie pathogenesis and explain the characteristic hyperactivity of T and B cells and other immune cells in active disease. Tyrosine kinases play a central role in signaling processes in cells known to be important in the pathogenesis of autoimmune diseases. Considerable progress has been made in understanding the function of tyrosine kinases in immune cell signaling pathways. In this review, we will summarize the function of tyrosine kinases and their novel inhibitors from studies made in animal lupus models and systemic lupus erythematosus patients.
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