Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 6, Issue 2, Pages 257-268Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.09.85
Keywords
airway inflammation; asthma; combination therapy; corticosteroid; corticosteroid insensitivity; leukotriene-receptor antagonist; smoker; smoking cessation; theophylline
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Cigarette smoking is common in asthma and is associated with poor symptom control and a reduced therapeutic response to inhaled and oral corticosteroids as compared with nonsmokers with asthma. This review examines the range of adverse health effects of smoking in asthma, the inflammatory mechanisms that may influence the efficacy of current drugs and discusses potential future therapeutic directions.
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