Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 5, Issue 5, Pages 547-556Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.09.45
Keywords
allergy; atopy; epithelial cell; inflammation; lung; skin; Th2; TSLP
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Funding
- NIH [A1068731, AI044259, AR055695, AI079951]
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Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiation and progression of allergic inflammatory diseases. In this review, we will discuss the role of TSLP in atopic diseases, as well as its function in immune homeostasis.
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