Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 5, Issue 6, Pages 765-777Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.09.66
Keywords
magnetic resonance imaging; molecular imaging; MRI; multiple sclerosis; PET; positron emission tomography; radiotracer; single-photon emission computerized tomography; SPECT
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Funding
- Medical Research Council [G9901399] Funding Source: Medline
- MRC [G9901399] Funding Source: UKRI
- Medical Research Council [G9901399] Funding Source: researchfish
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Molecular imaging has had little application to multiple sclerosis thus far. However, advances in preclinical studies and proofs-of-principle provided for other inflammatory disorders highlight the potential for using positron emission tomography, single-photon emission computerized tomography or MRI-based molecular imaging methods to define the distribution and trafficking of specific immune effector cells, or to follow changes in specific molecular neuropathology in multiple sclerosis. If this promise can be realized, novel insights into the dynamics of in vivo multiple sclerosis neuropathology can be expected. Furthermore, powerful new approaches to testing the pharmacology of novel therapeutics will become possible. Molecular imaging could also contribute to 'personalizing' treatments for better outcomes.
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