Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 12, Issue 6, Pages 811-837Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERA.12.53
Keywords
calcitriol; cancer risks; differentiation; DN-101; epidemiology; pharmacokinetics; polymorphisms; proliferation regulation; VDR; vitamin D analog
Categories
Ask authors/readers for more resources
Vitamin D has long been known for its physiological role in mineral homeostasis through its actions on the intestines, kidneys, parathyroid glands and bone. However, recent observations of antiproliferative, prodifferentiating and antiangiogenic effects elicited by the bioactive form of vitamin D (1,25[OH](2)D-3) in a broad range of cancers is less well understood. Here, we review the increasing epidemiological and experimental evidence that supports the development of 1,25(OH)(2)D-3 and vitamin D analogs as preventative and therapeutic anticancer agents. Furthermore, this review summarizes the preclinical and clinical studies of vitamin D and its analogs over the past decade, indicating the current problems of dose-limiting toxicity from hypercalcemia and large interpatient variability in pharmacokinetics. A better understanding of how genetic variants influence vitamin D status should not only improve cancer risk predictions, but also promote the development of vitamin D analogs with more specific actions to improve therapeutic outcomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available