Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 10, Issue 12, Pages 1945-1954Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERA.10.131
Keywords
gene-expression profiling; global approach; microarray; multimarker analysis; pathway-specific approach; urothelial carcinoma
Categories
Funding
- NIH [CA-70903, CA-14089, CA-86871, CA-103455]
- National Cancer Institute [CA-71921]
Ask authors/readers for more resources
Despite being a common cancer worldwide, management of transitional cell carcinoma of the bladder currently relies primarily on clinical staging and histopathologic parameters. Assaying alterations in molecular pathways can contribute valuable information that can accurately predict outcome and chemotherapeutic response in individual patients with bladder cancer. Medium- to high-throughput gene-expression profiling technologies are now allowing multiplexed assessment of alterations responsible for the genesis and progression of bladder tumors. These investigations employ global or pathway-based approaches to define molecular signatures that can predict prognosis independent of traditional clinical performance metrics. Prognostic panels generated using these strategies can also elucidate the biology of tumor progression and identify potential therapeutic targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available