Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 10, Issue 9, Pages 1389-1394Publisher
EXPERT REVIEWS
DOI: 10.1586/ERA.10.127
Keywords
chronic lymphocytic leukemia; clinical trials; comorbidity; elderly; treatment
Categories
Funding
- NIH [NCI PO1 CA81538]
- NATIONAL CANCER INSTITUTE [P01CA081534] Funding Source: NIH RePORTER
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Chronic lymphocytic leukemia (CLL) remains incurable, but over the past decade there have been major advances in the understanding of the pathophysiology of CLL and in the treatment of this disease. This has led to greatly increased response rates and durations of response, as well as improved survival. CLL is a disease of the elderly and not all patients are eligible for the aggressive upfront chemoimmunotherapy regimens that are resulting in improved response rates and survival, so what is the optimal treatment approach for more frail elderly patients? It is highly likely that our treatment approaches will continue to evolve as the results of ongoing clinical trials are released. The age range of patients involved in clinical trials is not representative of this disease, and more research is required in patients who are representative of the majority of CLL patients seen in practice before we will see outcome improvements in these more elderly and often more frail patient populations.
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