Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 9, Issue 3, Pages 365-371Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737140.9.3.365
Keywords
clinical features; pathogenesis; T-cell prolymphocytic leukemia; treatment
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T-cell prolymphocytic leukemia is a rare post-thymic lymphoid disorder, which has distinctive clinical, morphologic, immunophenotypic and cytogenetic features. It has previously been associated with an aggressive course, poor response to conventional chemotherapy and a short median survival. Treatment with purine analogs and the monoclonal antibody alemtuzumab has resulted in significantly higher response rates and increased survival. However, responses are transient and allogeneic hematopoietic progenitor-cell transplantation remains the only potential curative option. The proportion of patients eligible for transplant is low, owing to the older age group of patients, and nonmyeloablative transplantation is a promising alternative that needs to be explored.
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