4.5 Article

Carbapenem-resistant Gram-negative bacteria: how to prioritize infection prevention and control interventions in resource-limited settings?

Journal

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
Volume 11, Issue 2, Pages 147-157

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1586/ERI.12.164

Keywords

Acinetobacter baumannii; antimicrobial stewardship; carbapenem resistance; Enterobacteriaceae; epidemiology; Escherichia coli; Gram negative; infection prevention; Klebsiella pneumoniae; Pseudomonas aeruginosa; resource-limited settings

Funding

  1. National Research University Project of the Thailand Office of Higher Education Commission
  2. Infectious Diseases and Infection Control Research Unit

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Emergences of carbapenem-resistant Gram-negative bacteria (CRGNB) have heightened global awareness of the prioritization of infection prevention and control (IPC) interventions to minimize infections attributed to these bacteria. Effective new antibiotic drugs for CRGNB are estimated to be at least 5 years off completion of trials and approval for use. Hence, effective IPC strategies remain at the core of clinical care and research for patients with CRGNB infection. The authors summarize current evidence and viewpoints for IPC strategies as related to the emergence, transmission and prevention of CRGNB.

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