Journal
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
Volume 10, Issue 8, Pages 917-934Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERI.12.78
Keywords
acquired resistance; colistimethate sodium; colistin sulfate; combination therapy; multidrug-resistant bacteria; polymyxin
Ask authors/readers for more resources
The emergence of multidrug-resistant Gram-negative bacteria that cause nosocomial infections is a growing problem worldwide. Colistin was first introduced in 1952 and was used until the early 1980s for the treatment of infections caused by Gram-negative bacilli. In vitro, colistin has demonstrated excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Recent clinical findings regarding colistin activity, pharmacokinetic properties, clinical uses, emerging resistance, toxicities and combination therapy have been reviewed. Recent approaches to the use of colistin in combination with other antibiotics hold promise for increased antibacterial efficacy. It is probable that colistin will be the 'last-line' therapeutic drug against multidrug-resistant Gram-negative pathogens in the 21st century.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available