Journal
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
Volume 8, Issue 5, Pages 589-606Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERI.10.36
Keywords
anemia; children; infants; intermittent preventive therapy; malaria; pregnancy; school children; seasonal
Funding
- MRC UK
- Pfizer
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Intermittent preventive treatment (IPT) against malaria is a malaria control strategy aimed at reducing the burden of malaria in certain high-risk groups, namely pregnant women and children. Three strategies - IPT in pregnancy (IPTp), infants (IPTi) and children (IPTc) - are reviewed here focusing on the mechanism of action, choice of drugs available, controversies and future research. Drugs for IPT need to be co-formulated, long acting, safe and preferably administered as a single dose. There is no obvious replacement for sulfadoxine pyrimethamine, the most commonly utilized drug combination. All strategies face similar problems of rising drug resistance, falling malaria transmission and a policy shift from controlling disease to malaria elimination and eradication. IPT is an accepted form of malaria control, but to date only IPTp has been adopted as policy.
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